Pim1 mutation

Author: wzot

August undefined, 2024

WebDec 2, 2024 · To the right of the BCL2-CREBBP patient group on the heat map, there are patients with MYD88 or CD79B mutations, and about 1/4 (6/23) of them also carry PIM1 mutations. However, PIM1 mutations also appear in both JAK-STAT6-related type and BCL2-CREBBP. WebFeb 5, 2024 · PIM1 has previously been reported as frequently mutated in PCNSL, and we observed mutations in 27 (75%) of 36 patients. 5,11 The PIM1 mutations we identified were most commonly missense (n = 21) but also included in-frame insertion/deletion (n = 4), frameshift (n = 1), or splice site variant (n = 1).

PIM1 Gene - Somatic Mutations in Cancer

WebConsistently, we found that the mutation frequencies of PIM1 and CD79B were significantly higher in DLBCL patients with the non-GCB subtype than in those with the GCB subtype. In addition, we were able to detect ctDNA mutations in 64 (75.3%) out of 85 patients in the training set and 67 (79.8%) out of 84 patients in the validation set. WebNov 15, 2024 · Conclusions: Our findings reveal that PIM1 mutation is involved in the pathogenesis of DLBCL, suggesting that detection of PIM1 mutations with incorporation of our PIM1 mutation-related gene signature will be helpful for identifying DLBCL patients at high risk of progression and might provide predictive information for the design of … donovan ivory

High PIM1 expression is a biomarker of T-cell acute ... - Nature

WebFeb 9, 2024 · Mutational analysis recognized two groups. The CDP (including CD79B and/or PIM1 mutations) group was identified in 27 cases (67.5%), and the non-CDP (without CD79B and PIM1 mutations) group... WebFeb 2, 2024 · In primary acute myeloid leukemia and B-cell acute lymphoblastic leukemia, PIM1 activation has been related to MLL translocations, BCR-ABL1 fusion, and JAK2 and … WebNov 15, 2002 · In addition, the pim1 mutation suppressed the effect of Ned1 overproduction on nuclear shape (see below). We also tested whether the ned1 + gene interacts with dis … donovan j45

Paper: PIM1 Genetic Alterations Associated with Distinct …

BTG2 gene predicts poor outcome in PT-DLBCL JIR

WebMar 11, 2024 · Mutation of PIM1 is the second most common mutation after CDKN2A in rrDLBCL and its mutation rate was slightly higher in ABC-type DBCL than in GCB-type DLBCL, as shown in a previous study . PIM1 is a multifunctional gene that activates SOCS1 and SOCS3 to act as negative regulators of the JAK–STAT pathway . In ... WebMar 30, 2024 · PIM1 has been described as a coactivator of MYC promoting tumorigenesis. 61 Although we could not detect a higher incidence of MYC alterations in patients with an adverse clinical behavior, PIM1 somatic mutations were associated with a shorter duration of response and may represent an alternative mechanism of lymphomagenesis. ra 10067WebSep 1, 2024 · PIM1 mutations were recently found to reduce sensitivity to ibrutinib in ABC-DLBCL by stabilizing PIM1 and affecting upstream regulators and downstream targets of … ra 10066

"WebApr 12, 2024 · Here, we integrated targeted sequencing and transcriptome analysis to explore the pathogenic role of PIM1 mutations and as a personalized therapeutic … " - Pim1 mutation

Pim1 mutation

PIM1 Pim-1 proto-oncogene, serine/threonine kinase [ (human)]

WebPIM1 (COSG362) Genomic coordinates 6:37170203..37175426 (positive strand) Synonyms PIM, CCDS4830.1, P11309, ENSG00000137193.13, NM_002648.3, … WebGene name PIM1 AA mutation p.G50D (Substitution - Missense, position 50 , G D ) CDS mutation c.149G>A (Substitution, position 149 , G A ) Nucleotides inserted n/a Genomic coordinates GRCh38, 6:37170839..37170839, view Ensembl contig CDD NP_002639.1 HomoloGene 11214 , view the multiple sequence alignment Ever confirmed somatic? …

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WebNov 28, 2024 · Knockdown of PIM1 sensitizes cells of differing MYCN status to ALK inhibitors, and in patient-derived xenografts of high-risk NB harboring ALK mutations, the combination of the ALK inhibitor ceritinib and PIM1 inhibitor AZD1208 shows significantly enhanced anti-tumor efficacy relative to single agents. WebMar 5, 2024 · We identified recurrent oncogenic mutations in GI-DLBCL, including those in TP53, MUC16, B2M, CCND3, HIST1H1C, NEB, and ID3. Compared with nodal DLBCL, GI-DLBCL exhibited an increased mutation frequency of TP53 and reduced mutation frequencies of PIM1, CREBBP, BCL2, KMT2D, and EZH2.

WebVS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell). ... attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD ... WebGene view. The gene view histogram is a graphical view of mutations across PIM1. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the ...

WebPIM-1 is an estrogen receptor alpha target gene adds a novel potential mechanism by which estrogens can contribute to breast cancer cell proliferation and … WebCompared with classic DLBCL, PT-DLBCL showed an increased mutation frequency of PIM1, MYD88, BTG2, while NOTCH1 appeared exclusive mutated with PIM1, MSH3 and ETV6. Cox risk model regression analysis showed that age ≥ 60 years, IPI 3– 5 points, BTG2 gene mutation and extranodal organ invasion suggested poor prognosis. Finally, …

WebFeb 9, 2024 · We developed a new molecular classification to divide CNS DLBCL into CDP and non-CDP groups based on CD79B and PIM1 mutational status. Patients with PIM1 …

WebThese encompass, putative driver missense mutations, and amplifications, splice, missense, in frame, and truncating mutations of unknown significance. Pim-1 is one of … ra 1003WebAug 23, 2024 · Moreover, PIM1, MYD88, and KMT2D mutations were detected more frequently in CD5+ DLBCL cases (P < 0.05). According to multivariate analysis, MYC/BCL2 double expression and ABC subtype were correlated with unfavorable overall survival (OS). High mRNA expression of SERPINA9 and MME showed a significant correlation with a … ra 10005WebNov 28, 2024 · Knockdown of PIM1 sensitizes cells of differing MYCN status to ALK inhibitors, and in patient-derived xenografts of high-risk NB harboring ALK mutations, the … ra 10022WebPIM1 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, PIM1 Genome Browser, PIM1 References PIM1 - Explore an overview of PIM1, with a histogram displaying coding mutations, full … donovan jay ehrmanWebNov 23, 2024 · PIM1 mutations were involved in immunoglobulin-related immune response, complement activation, B cell mediated … ra 10028WebNov 23, 2024 · PIM1 mutations were involved in immunoglobulin-related immune response, complement activation, B cell mediated immunity, B cell activation, antigen binding, and cytokine activity, which contributed to the signaling pathways of tumor microenvironment (e.g. cytokine- cytokine receptor interaction, chemokine signaling pathway, IL-17 … donovan jeter statsWebWe integrated targeted sequencing and transcriptome analysis to explore the pathogenic role of PIM1 mutations and as a personalized therapeutic target in PIM1-mutated … donovan jackson iowa state