Terpendole
WebTerpendole I: ChEBI ID CHEBI:144412: Stars This entity has been manually annotated by a third party. Submitter Mark Williams: Supplier Information Download Molfile XML SDF: … WebTerpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of …
Terpendole
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WebJul 6, 2024 · Fraction 60%-2 (249 mg) was subjected to preparative high-performance liquid chromatography (HPLC) to give NK12838 (6) and new terpendole N (1). Purification from fraction 80%-2 (214 mg) by preparative HPLC allowed isolation of three peaks, new terpendole O (2), terpendole C (7) , and a third peak. The third peak was, however, … WebMay 21, 2014 · Terpendole E (1) is composed with some ring units; indole part with rings A, B and diterpene part from ring C to the tetrahydropyran ring F, which connects with fused cyclopentene ring C. (Fig. 1). The ring A–C portion can be recognized as the substructure of indole fused with cyclopentene ring C at C-2 and C-3 double bond of the indole.
WebFeb 1, 2003 · Terpendole E Is a Selective Inhibitor of Eg5 Rather Than an ACAT Inhibitor. Since terpendole derivatives were isolated as ACAT inhibitors, we next compared the inhibitory activity of TerE with that of other ACAT inhibitors such as terpendole derivatives and FR179254. The results are summarized in Table 1. It has been reported that TerC … WebAbstract. Two new prenylated indole diterpenoids, tolypocladins K and L (1 and 2), together with a known analog terpendole L (3), were isolated from the solid fermentation culture …
WebDec 15, 2016 · Isolation of a terpendole E analog with stronger kinesin Eg5 inhibitory activity: Overproduction of bioactive compounds may cause production of shunt metabolites with improved bioactivity. Indeed, a new terpendole E analog was isolated from a terP-knockout strain that stably overproduced terpendole E. 11 After prolonged culture, ...
WebTerpendole E is first natural product found to inhibit mitotic kinesin Eg5, but its inhibitory mechanism remains to be revealed. Here, we report the effects of terpendole E and …
WebFeb 1, 2003 · Terpendole E Is a Selective Inhibitor of Eg5 Rather Than an ACAT Inhibitor. Since terpendole derivatives were isolated as ACAT inhibitors, we next compared the … free game card gamesWebTerpendole C. Cat. No.: HY-N10224. Data Sheet Handling Instructions. Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase ( ACAT ). For research use only. bls walthamWebTo reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase … free game chat softwareWebThe application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described. free game catalogsWebNov 7, 2024 · Diterpenes are one of the classes of natural products with about 7000 structures. The basic skeleton of diterpene contains 20 carbon atoms. Microbes contain … bls walk-in appointmentWebMay 5, 2014 · Terpendole E (TerE) is the first natural product that inhibits mitotic kinesin Eg5 (kinesin spindle protein). Recently, TerE is suggested to have a different binding site and/or inhibitory ... bls waltham usWebMar 19, 2014 · Terpendole E is first natural product found to inhibit mitotic kinesin Eg5, but its inhibitory mechanism remains to be revealed. Here, we report the effects of terpendole E and 11ketopaspaline (a new natural terpendole E analogue) on the Eg5–microtubule interaction and in several Eg5 mutants. 11-Ketopaspaline is a shunt product from … bls wake forest nc